AI built to accelerate biotech and life-science R&D.

Built to fit your institution. Designed for easy deployment. Ready for regulated environments.

Waffoo AI delivers domain-specific AI tools that fit your institution's approved models, data, workflows, privacy, and governance requirements, with traceable outputs and hands-on training so adoption scales across your organization.

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Waffoo Search opens to everyone on October 21. Already registered? You get in on October 14.

Waffoo Search results for “mRNA vaccine efficacy”: the knowledge map on the left, the ranked result cards with DOI and PMID on the right

Model-agnosticRuns on your institution's approved model.

Privacy-awareYour security, data residency, and model governance.

Built around your dataInternal databases connect through APIs beside 30+ external sources.

Regulatory-readyA credibility report on every search: provenance, confidence, process.

How it works

From a question to the whole field in one screen.

Knowledge map

Full evidence landscape.Literature · Trials · Regulatory · Books · Conferences · Internal data

Every result in an interactive knowledge map, linked by relevance, to see the whole field at once.

One query, 30+ databases, one map
Papers, books, lectures, trials, and reports as nodes on one map
Hover a node to read the source, click to open it
Filter by type, year, or relevance

Open Waffoo Search

Credibility

Without hallucinated citations, retracted evidence, or retrieval bias.

Every displayed citation comes from a retrieved source record with a resolvable identifier: DOI · PMID · NCT · source URL. Hallucinated citations are structurally impossible.

Provenance on every card: DOI · PMID · NCT · source URL
Retraction checks against Crossref and Retraction Watch before ranking
Domain-trained evidence ranking: scientific influence, clinical authority, integrity signals, source authority

Open Waffoo Search

PaperPubMed

A Comprehensive Review of mRNA Vaccines.

Gote V, Bolla PK, Kommineni N +5

2023 · 446 citations

Review

mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development…

DOI 10.3390/ijms24032700·PMID 36769023

Connections Save

ReportClinical TrialClinicalTrials.gov

A Phase 2b, Double-Blind, Multi-Center, Randomized, Comparator-Controlled Trial to Determine the Relative Efficacy, Safety, and Immunogenicity of an Oral COVID-19 Vaccine.

Vaxart

2024 · N=5485

Active Not RecruitingPhase 2

Conditions: SARS-CoV-2, COVID-19 · Interventions: VXA-CoV2-3.1, COMIRNATY®, VXA-CoV2-3.3 · The primary objective of the study is to determine the…

NCT06672055

Connections Save

BookGoogle Books

PLOTKIN’S VACCINES

Plotkin’s Vaccines

Orenstein WA, Offit PA, Edwards KM, Plotkin SA · Elsevier

2023 · 8th ed. · 1,808 pp

Found in Chapter 22 — “…lipid-nanoparticle delivery of mRNA vaccines and correlates of protection…”

ISBN 978-0-323-79058-1

Connections Save

PaperPubMed

Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.

Wakefield AJ, Murch SH, Anthony A +10

1998 · The Lancet · retracted 2010

DOI 10.1016/S0140-6736(97)11096-0·PMID 9500320

Connections Save

Regulatory-ready

AI outputs designed around regulatory expectations.Trace it. Document it. Defend it.

Every Waffoo Search generates a credibility report by default, showing how the evidence was found, evaluated, and surfaced, so the output is not only useful but defensible when regulators ask how it was produced.

Every result is traceable to its source, with provenance recorded from retrieval to output.
Aligned with FDA credibility guidance and the FDA–EMA Good AI Practice principles.
The report is generated with your results, not after them.

See a sample report

mRNA-vaccine-efficacy-2026-09-01.xlsx

1Waffoo Search — Credibility Report

2How these results were retrieved, ranked and screened. Modeled on the FDA credibility assessment framework (FDA 2025 draft guidance; FDA + EMA Good AI Practice principles, 2026).

41 · Question & context of use

5Query as typedmRNA vaccine efficacy

6Query as executedmRNA vaccine efficacy

7Searched at8/31/2026, 7:54:26 PM

8Report generated8/31/2026, 7:56:45 PM

9Context of useEvidence discovery and prioritization in support of a human researcher. Waffoo Search is a decision-support tool.

112 · Query interpretation (AI-assisted)

12Detected intentEvidence Synthesis

13Confidence85%

14Classified byLarge language model — LLM classification path (provider chain: Groq → Cerebras → Gemini)

15Query expansion2 MeSH term(s) and 4 sub-queries used (listed on the Search Settings sheet)

173 · Retrieval process

18Step 1Intent classification & spell check (query-processor).

19Step 2Parallel multi-source retrieval — papers from PubMed, OpenAlex and Semantic Scholar; lectures, books and institutional reports (NIH, CDC, FDA…).

20Step 3Deduplication and merging of records that appear in more than one source.

21Step 4Semantic re-ranking — semantic embedding of the query, vector similarity search, reciprocal-rank fusion of keyword and semantic lists.

22Step 5Signal enrichment — citation and integrity signals attached to PubMed-indexed papers and factored into re-ranking.

23Filters appliedDate range: All time · Sources: All source types

24Results exported74 paper(s), 22 lecture(s), 46 book(s), 108 report(s)

264 · Provenance

27IdentifiersResult sheets carry each record’s source identifiers — DOI, PMID, ISBN or source URL — as provided by the source.

28Retrieval-gated citationsResults come only from retrieved source records: the system cannot cite a document it did not retrieve, so fabricated citations are structurally excluded.

305 · Integrity screening

31RetractionsPapers with a PubMed ID are screened against retraction and correction records; papers flagged as retracted are excluded from competitive ranking.

336 · Ranking rationale

34SignalsRanking combines keyword and semantic relevance with evidence signals — citations and scientific influence, integrity signals, study type and source metadata.

35What scores meanRanking scores are prioritization aids, not judgments of clinical validity. Appraisal of the evidence remains with the reader.

377 · Known limitations & bias

38CoverageSources skew toward English-language and PubMed-indexed literature; regional and non-English work is under-represented.

39Citation signalsCitation-based signals structurally favor older, established work; recent findings can rank below their eventual importance.

40Semantic rankingEmbedding and re-ranking models inherit biases of their training data; keyword results are fused in to keep them competitive.

41Intent classificationThe AI classifier can misread specialist shorthand — its confidence and classification path are reported above, and Waffoo Tune allows manual override.

42Automation biasTop-ranked does not mean best evidence. Ordering is a reading aid; inclusion decisions should not be delegated to rank position.

448 · Human oversight

45StatementThese results were retrieved for review and selection by a qualified human. This report is an audit record of what was shown, in what order, and why.

479 · System & references

48Generated byWaffoo Search (search.waffooai.com)

49FrameworkFDA (2025, draft) — AI to Support Regulatory Decision-Making for Drug and Biological Products; FDA + EMA (2026) — Guiding Principles of Good AI Practice in Drug Development.

Search SettingsPapersLecturesBooksReportsCredibility Report+

Waffoo Library

Keep what matters, in one place.

Save any result with one click. Add notes, upload PDFs, record a voice memo. Everything you keep becomes a node you can search again.

Save papers, books, lectures, and reports
Notes, uploads, and recordings alongside the sources
Export to Excel with the Credibility Report

Open the Library

PapermRNA vaccinesPubMed

Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacy.

Xu Ma, Shaoli Liu, Shuhui Zhang +19

2025 · 17 citations · saved Sept 4

Your note — “Compare their lipid ratios with our August formulation before the Friday meeting.”

DOI 10.1038/s41467-025-63965-3·PMID 41057328

Open in Search Edit note

UploadmRNA vaccinesPDF · 2.1 MB

LNP-formulation-protocol-v3.pdf

Uploaded Sept 4, 2026 · 14 pages · text extracted

IndexedPrivate to you

Sits on the map beside the papers it cites, so your own protocol is searched with the literature, not apart from it.

LINKED 3 papers on the map

Open in Search Add note

RecordingJournal club12:40 · transcribed

Journal club — oral COVID-19 vaccine candidates

Recorded Sept 4, 2026 · Waffoo Library

Transcript — “…check whether the comparator arm in the Phase 2b matches the Phase 3 design before we cite it…”

LINKED Vaxart trial · NCT06672055

Open in Search Add note

ReportClinical TrialJournal clubClinicalTrials.gov

A Phase 2b, Double-Blind, Multi-Center, Randomized, Comparator-Controlled Trial to Determine the Relative Efficacy, Safety, and Immunogenicity of an Oral COVID-19 Vaccine.

Vaxart

2024 · N=5485 · saved Sept 4

Active Not RecruitingPhase 2

NCT06672055

Open in Search Add note

Waffoo Tune

See how Waffoo read your question. Then steer it.

Tune shows the research intent it detected, the MeSH terms it expanded, and the exact sub-queries sent to each database. Change any of them and search again.